| 1 | Barbershop (MGM) | Sep 13 - Sep 15, 2002 | $20,627,433 | 1,605 | $12,852 |
| 2 | Blue Streak (Sony / Columbia) | Sep 17 - Sep 19, 1999 | $19,208,806 | 2,735 | $7,023 |
| 3 | Burn After Reading (Focus) | Sep 12 - Sep 14, 2008 | $19,127,911 | 2,651 | $7,215 |
| 4 | Cloudy with a Chance of Meatballs (Sony / Columbia) | Sep 18 - Sep 20, 2009 | $30,304,539 | 3,119 | $9,716 |
| 5 | Contagion (Warner Bros.) | Sep 09 - Sep 11, 2011 | $22,403,596 | 3,222 | $6,953 |
| 6 | Dolphin Tale (Warner Bros.) | Sep 23 - Sep 25, 2011 | $19,152,401 | 3,507 | $5,461 |
| 7 | Don't Say a Word (Fox) | Sep 28 - Sep 30, 2001 | $17,090,474 | 2,802 | $6,099 |
| 8 | Double Jeopardy (Paramount) | Sep 24 - Sep 26, 1999 | $23,162,542 | 2,547 | $9,094 |
| 9 | Eagle Eye (Paramount / DreamWorks) | Sep 26 - Sep 28, 2008 | $29,150,801 | 3,510 | $8,305 |
| 10 | Easy A (Sony / Screen Gems) | Sep 17 - Sep 19, 2010 | $17,734,040 | 2,856 | $6,209 |
| 11 | Finding Nemo 3D (Disney) | Sep 14 - Sep 16, 2012 | $16,687,773 | 2,904 | $5,746 |
| 12 | Flightplan (Disney) | Sep 23 - Sep 25, 2005 | $24,630,972 | 3,424 | $7,194 |
| 13 | Hotel Transylvania (Sony / Columbia) | Sep 28 - Sep 30, 2012 | $42,522,194 | 3,349 | $12,697 |
| 14 | In & Out (Paramount) | Sep 19 - Sep 21, 1997 | $15,019,821 | 1,992 | $7,540 |
| 15 | Just Like Heaven (DreamWorks) | Sep 16 - Sep 18, 2005 | $16,409,192 | 3,508 | $4,678 |
| 16 | Lakeview Terrace (Sony / Screen Gems) | Sep 19 - Sep 21, 2008 | $15,004,283 | 2,464 | $6,089 |
| 17 | Legend of the Guardians: The Owls of Ga'Hoole (Warner Bros.) | Sep 24 - Sep 26, 2010 | $16,112,211 | 3,575 | $4,507 |
| 18 | Looper (Sony / TriStar) | Sep 28 - Sep 30, 2012 | $20,801,552 | 2,992 | $6,952 |
| 19 | Moneyball (Sony / Columbia) | Sep 23 - Sep 25, 2011 | $19,501,302 | 2,993 | $6,516 |
| 20 | Once Upon a Time in Mexico (Sony / Columbia) | Sep 12 - Sep 14, 2003 | $23,423,307 | 3,282 | $7,137 |
| 21 | Open Season (2006) (Sony / Columbia) | Sep 29 - Oct 01, 2006 | $23,624,418 | 3,833 | $6,163 |
| 22 | Remember the Titans (Disney) | Sep 29 - Oct 01, 2000 | $20,905,831 | 1,865 | $11,210 |
| 23 | Resident Evil: Afterlife (Sony / Screen Gems) | Sep 10 - Sep 12, 2010 | $26,650,264 | 3,203 | $8,320 |
| 24 | Resident Evil: Apocalypse (Sony / Screen Gems) | Sep 10 - Sep 12, 2004 | $23,037,046 | 3,284 | $7,015 |
| 25 | Resident Evil: Extinction (Sony / Screen Gems) | Sep 21 - Sep 23, 2007 | $23,679,360 | 2,828 | $8,373 |
| 26 | Resident Evil: Retribution (Sony / Screen Gems) | Sep 14 - Sep 16, 2012 | $21,052,227 | 3,012 | $6,989 |
| 27 | Righteous Kill (Overture) | Sep 12 - Sep 14, 2008 | $16,287,944 | 3,152 | $5,167 |
| 28 | Rush Hour (New Line) | Sep 18 - Sep 20, 1998 | $33,001,803 | 2,638 | $12,510 |
| 29 | Sky Captain and the World of Tomorrow (Paramount) | Sep 17 - Sep 19, 2004 | $15,579,942 | 3,170 | $4,915 |
| 30 | Stigmata (MGM) | Sep 10 - Sep 12, 1999 | $18,309,666 | 2,899 | $6,316 |
| 31 | Surrogates (Disney) | Sep 25 - Sep 27, 2009 | $14,902,531 | 2,951 | $5,050 |
| 32 | Sweet Home Alabama (Disney) | Sep 27 - Sep 29, 2002 | $35,648,610 | 3,293 | $10,826 |
| 33 | The Exorcism of Emily Rose (Sony / Screen Gems) | Sep 09 - Sep 11, 2005 | $30,054,493 | 2,981 | $10,082 |
| 34 | The First Wives Club (Paramount) | Sep 20 - Sep 22, 1996 | $18,913,411 | 1,922 | $9,840 |
| 35 | The Forgotten (Sony / Columbia) | Sep 24 - Sep 26, 2004 | $21,023,166 | 3,104 | $6,773 |
| 36 | The Game Plan (Disney) | Sep 28 - Sep 30, 2007 | $22,951,574 | 3,103 | $7,397 |
| 37 | The Guardian (2006) (Disney) | Sep 29 - Oct 01, 2006 | $18,006,358 | 3,241 | $5,556 |
| 38 | The Kingdom (Universal) | Sep 28 - Sep 30, 2007 | $17,136,607 | 2,793 | $6,136 |
| 39 | The Lion King 3D (Disney) | Sep 16 - Sep 18, 2011 | $30,151,614 | 2,330 | $12,941 |
| 40 | The Rundown (Universal) | Sep 26 - Sep 28, 2003 | $18,554,226 | 3,152 | $5,886 |
| 41 | The Town (Warner Bros.) | Sep 17 - Sep 19, 2010 | $23,808,032 | 2,861 | $8,322 |
| 42 | The Tuxedo (DreamWorks) | Sep 27 - Sep 29, 2002 | $15,050,491 | 3,022 | $4,980 |
| 43 | Tim Burton's Corpse Bride (Warner Bros.) | Sep 23 - Sep 25, 2005 | $19,144,717 | 3,204 | $5,975 |
| 44 | Transporter 2 (Fox) | Sep 02 - Sep 04, 2005 | $16,540,490 | 3,303 | $5,008 |
| 45 | Tyler Perry's I Can Do Bad All By Myself (Lionsgate) | Sep 11 - Sep 13, 2009 | $23,447,851 | 2,255 | $10,398 |
| 46 | Tyler Perry's The Family That Preys (Lionsgate) | Sep 12 - Sep 14, 2008 | $17,381,578 | 2,070 | $8,397 |
| 47 | Underworld (Sony / Screen Gems) | Sep 19 - Sep 21, 2003 | $21,753,138 | 2,915 | $7,462 |
| 48 | Wall Street: Money Never Sleeps (Fox) | Sep 24 - Sep 26, 2010 | $19,011,188 | 3,565 | $5,333 |
| 49 | Zoolander (Paramount) | Sep 28 - Sep 30, 2001 | $15,525,043 | 2,507 | $6,193 |
| 50 | jackass: number two (Paramount) | Sep 22 - Sep 24, 2006 | $29,002,260 | 3,059 | $9,481 |
