| 1 | The First Wives Club (Paramount) | Sep 20 - Sep 22, 1996 | $18,913,411 | 1,922 | $9,840 |
| 2 | Rush Hour (New Line) | Sep 18 - Sep 20, 1998 | $33,001,803 | 2,638 | $12,510 |
| 3 | Blue Streak (Sony / Columbia) | Sep 17 - Sep 19, 1999 | $19,208,806 | 2,735 | $7,023 |
| 4 | Double Jeopardy (Paramount) | Sep 24 - Sep 26, 1999 | $23,162,542 | 2,547 | $9,094 |
| 5 | Remember the Titans (Disney) | Sep 29 - Oct 01, 2000 | $20,905,831 | 1,865 | $11,210 |
| 6 | Barbershop (MGM) | Sep 13 - Sep 15, 2002 | $20,627,433 | 1,605 | $12,852 |
| 7 | Sweet Home Alabama (Disney) | Sep 27 - Sep 29, 2002 | $35,648,610 | 3,293 | $10,826 |
| 8 | Once Upon a Time in Mexico (Sony / Columbia) | Sep 12 - Sep 14, 2003 | $23,423,307 | 3,282 | $7,137 |
| 9 | Underworld (Sony / Screen Gems) | Sep 19 - Sep 21, 2003 | $21,753,138 | 2,915 | $7,462 |
| 10 | The Rundown (Universal) | Sep 26 - Sep 28, 2003 | $18,554,226 | 3,152 | $5,886 |
| 11 | Resident Evil: Apocalypse (Sony / Screen Gems) | Sep 10 - Sep 12, 2004 | $23,037,046 | 3,284 | $7,015 |
| 12 | The Forgotten (Sony / Columbia) | Sep 24 - Sep 26, 2004 | $21,023,166 | 3,104 | $6,773 |
| 13 | The Exorcism of Emily Rose (Sony / Screen Gems) | Sep 09 - Sep 11, 2005 | $30,054,493 | 2,981 | $10,082 |
| 14 | Flightplan (Disney) | Sep 23 - Sep 25, 2005 | $24,630,972 | 3,424 | $7,194 |
| 15 | Tim Burton's Corpse Bride (Warner Bros.) | Sep 23 - Sep 25, 2005 | $19,144,717 | 3,204 | $5,975 |
| 16 | jackass: number two (Paramount) | Sep 22 - Sep 24, 2006 | $29,002,260 | 3,059 | $9,481 |
| 17 | Open Season (2006) (Sony / Columbia) | Sep 29 - Oct 01, 2006 | $23,624,418 | 3,833 | $6,163 |
| 18 | Resident Evil: Extinction (Sony / Screen Gems) | Sep 21 - Sep 23, 2007 | $23,679,360 | 2,828 | $8,373 |
| 19 | The Game Plan (Disney) | Sep 28 - Sep 30, 2007 | $22,951,574 | 3,103 | $7,397 |
| 20 | Burn After Reading (Focus) | Sep 12 - Sep 14, 2008 | $19,127,911 | 2,651 | $7,215 |
| 21 | Eagle Eye (Paramount / DreamWorks) | Sep 26 - Sep 28, 2008 | $29,150,801 | 3,510 | $8,305 |
| 22 | Tyler Perry's I Can Do Bad All By Myself (Lionsgate) | Sep 11 - Sep 13, 2009 | $23,447,851 | 2,255 | $10,398 |
| 23 | Cloudy with a Chance of Meatballs (Sony / Columbia) | Sep 18 - Sep 20, 2009 | $30,304,539 | 3,119 | $9,716 |
| 24 | Resident Evil: Afterlife (Sony / Screen Gems) | Sep 10 - Sep 12, 2010 | $26,650,264 | 3,203 | $8,320 |
| 25 | The Town (Warner Bros.) | Sep 17 - Sep 19, 2010 | $23,808,032 | 2,861 | $8,322 |
| 26 | Wall Street: Money Never Sleeps (Fox) | Sep 24 - Sep 26, 2010 | $19,011,188 | 3,565 | $5,333 |
| 27 | Contagion (Warner Bros.) | Sep 09 - Sep 11, 2011 | $22,403,596 | 3,222 | $6,953 |
| 28 | The Lion King 3D (Disney) | Sep 16 - Sep 18, 2011 | $30,151,614 | 2,330 | $12,941 |
| 29 | Dolphin Tale (Warner Bros.) | Sep 23 - Sep 25, 2011 | $19,152,401 | 3,507 | $5,461 |
| 30 | Moneyball (Sony / Columbia) | Sep 23 - Sep 25, 2011 | $19,501,302 | 2,993 | $6,516 |
| 31 | Resident Evil: Retribution (Sony / Screen Gems) | Sep 14 - Sep 16, 2012 | $21,052,227 | 3,012 | $6,989 |
| 32 | Hotel Transylvania (Sony / Columbia) | Sep 28 - Sep 30, 2012 | $42,522,194 | 3,349 | $12,697 |
| 33 | Looper (Sony / TriStar) | Sep 28 - Sep 30, 2012 | $20,801,552 | 2,992 | $6,952 |
| 34 | Riddick (Universal) | Sep 06 - Sep 08, 2013 | $19,030,375 | 3,107 | $6,125 |
| 35 | Insidious: Chapter 2 (FilmDistrict) | Sep 13 - Sep 15, 2013 | $40,272,103 | 3,049 | $13,208 |
| 36 | Prisoners (Warner Bros.) | Sep 20 - Sep 22, 2013 | $20,817,053 | 3,260 | $6,386 |
| 37 | Cloudy with a Chance of Meatballs 2 (Sony / Columbia) | Sep 27 - Sep 29, 2013 | $34,017,930 | 4,001 | $8,502 |
| 38 | No Good Deed (2014) (Sony / Screen Gems) | Sep 12 - Sep 14, 2014 | $24,250,283 | 2,175 | $11,150 |
| 39 | The Maze Runner (Fox) | Sep 19 - Sep 21, 2014 | $32,512,804 | 3,604 | $9,021 |
| 40 | The Equalizer (Sony / Columbia) | Sep 26 - Sep 28, 2014 | $34,137,828 | 3,236 | $10,549 |
| 41 | The Visit (2015) (Universal) | Sep 11 - Sep 13, 2015 | $25,427,560 | 3,069 | $8,285 |
| 42 | The Perfect Guy (Sony / Screen Gems) | Sep 11 - Sep 13, 2015 | $25,888,154 | 2,221 | $11,656 |
| 43 | Black Mass (Warner Bros.) | Sep 18 - Sep 20, 2015 | $22,635,037 | 3,188 | $7,100 |
| 44 | Maze Runner: The Scorch Trials (Fox) | Sep 18 - Sep 20, 2015 | $30,316,510 | 3,791 | $7,997 |
| 45 | Hotel Transylvania 2 (Sony / Columbia) | Sep 25 - Sep 27, 2015 | $48,464,322 | 3,754 | $12,910 |
| 46 | Sully (Warner Bros.) | Sep 09 - Sep 11, 2016 | $35,028,301 | 3,525 | $9,937 |
| 47 | The Magnificent Seven (2016) (Sony / Columbia) | Sep 23 - Sep 25, 2016 | $34,703,397 | 3,674 | $9,446 |
| 48 | Storks (Warner Bros.) | Sep 23 - Sep 25, 2016 | $21,311,407 | 3,922 | $5,434 |
| 49 | Deepwater Horizon (Lionsgate / Summit) | Sep 30 - Oct 02, 2016 | $20,223,544 | 3,259 | $6,205 |
| 50 | Miss Peregrine's Home for Peculiar Children (Fox) | Sep 30 - Oct 02, 2016 | $28,871,140 | 3,522 | $8,197 |
